Genome editing in stem cells

The development of targeted genome editing technique using custom-engineered sequence-specific nucleases (including CRISPR/Cas9) allowed genetic changes with greater precision. This technique has a widespread application in reprograming of stem cells to study disease outcomes. The rapid evolution of these two techniques over years and their relationship with one another has paved a way for understanding cellular interactions and regulation of transcription at molecular level with appreciable efficiency and flexibility.

  • CRISPR/Cas9 in genome editing
  • Genome editing for designer babies
  • DNA repair in stem cells
  • Generation of animal models by genome editing
  • Targeting genetic diseases by genome editing in stem cells

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